Research Associate, Department of Radiation Oncology

The Department of Radiation Oncology at the University of Virginia School of Medicine seeks a Research Associate to conduct research in the Larner/Genetta Lab. We have identified the transcription factor and master regulator of the epithelial-to-mesenchymal transition (EMT), ZEB1 as a key molecule that functions directly in the repair of DSBs by recruiting the repair pathway choice protein 53BP1 to DSBs. ZEB1 depletion enhances radio sensitivity and increases IR-induced chromosomal aberrations and also increases hyper-resection at DSBs resulting in a ZEB1-mediated alterations in PARP inhibitors (PARPi) sensitivity. Our long term goal is to exploit the ZEB1-53BP1 axis therapeutically to increase sensitivity to IR and to PARPi.

Qualified applicants are required to have a PhD in a biomedical field by start date. A background in DNA repair/DDR is strongly preferred but not required; candidate should have demonstrated proficiency in standard biochemical and molecular techniques. The successful applicant will be expected to independently design, execute and critically interpret experiments and to work both independently and as part of a team.

Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.

This is a restricted position; continuation is dependent on funding and satisfactory performance.

The position will remain open until filled.

TO APPLY:

Please apply through Workday at the following URL, https://uva.wd1.myworkdayjobs.com/UVAJobs , and search for requisition # R0034368.Internal applicants must apply through their UVA Workday profile and search “Find Jobs,” and search for requisition # R0034368. Complete an application online and attach the following documents:

• Cover letter
• CV/resume

The successful candidates will pass a criminal background check and pre-employment health screening. Please note that multiple documents can be uploaded in the box. Applications that do not contain all required documents will not receive full consideration.

For questions regarding the application process, please contact Jessica Russo, Recruiter, at sxv9zv@virginia.edu .

For further information regarding this position, please contact Dr. Thomas Genetta at tg5ke@virginia.edu .

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The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.