Research Scientist Biochemistry & Molecular Genetics, Yang Lab

The Yang Laboratory in the Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, is seeking 1-2 highly motivated Research Scientists (Sr. Postdoctoral Researchers) to join our growing research team.

The Yang Laboratory is dedicated to understanding the molecular mechanisms governing cellular stress responses, with a particular focus on mitochondrial stress, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and the integrated stress response (ISR). We combine state-of-the-art cryo-EM, protein biochemistry, biophysics, and cell biology to elucidate how these signaling pathways are regulated in health and disease.

Our long-term goal is to translate mechanistic discoveries into innovative therapeutic strategies for human diseases, including neurodegeneration, metabolic diseases, cardiovascular diseases, and cancer. For more information about the Yang Laboratory, please visit https://jieyang-lab.com .

The laboratory is housed within the University of Virginia School of Medicine and benefits from outstanding research infrastructure, including world-class cryo-EM facilities, collaborative interdisciplinary research programs, and a vibrant scientific community.

Successful candidates will investigate the molecular mechanisms of cellular stress response signaling using an interdisciplinary approach that integrates cryo-electron microscopy (cryo-EM), structural biology, protein biochemistry, and cell biology. Projects focus on uncovering the molecular basis of stress signaling and developing novel strategies to therapeutically modulate these pathways.

Initial appointments and reappointments to these positions may be made in increments of one to three years, contingent upon satisfactory performance and the availability of funding.

Research Scientists are expected to perform assigned tasks independently. In addition to a firm background in the particular field, Research Scientists should demonstrate the ability to lead small groups and work without additional supervision once objectives are defined and methods of approach are set. As Senior Professional Research Staff, they are not expected to provide formal guidance to students or otherwise participate in the instructional program.

Duties and Responsibilities

• Lead and conduct innovative research projects investigating the molecular mechanisms of cellular stress response signaling using structural biology, biochemistry, and cell biology approaches.
• Design and execute experiments, analyze and interpret data, and develop new experimental strategies.
• Contribute to manuscript preparation and publication in high-impact peer-reviewed journals.
• Present research findings at departmental seminars, national, and international scientific conferences.
• Develop independent research ideas and pursue fellowship and grant opportunities with mentorship from the Principal Investigator.
• Mentor graduate students, undergraduate researchers, and research staff as appropriate, and foster a collaborative laboratory environment.
• Contribute to laboratory operations, including maintaining research resources, ensuring compliance with laboratory safety policies, and participating in regular group meetings.

QUALIFICATIONS

Requires a doctoral degree or equivalent, preferably in Structural biology, Chemical biology, Biochemistry, or Cell biology . 3-5 years experience in an academic setting is preferred.

PHYSICAL DEMANDS:

This is primarily a sedentary job involving extensive use of beach work and desktop computers. The job does occasionally require traveling some distance to attend meetings, and programs.

Salary Range: $63,000-$70,000 annually, commensurate with qualifications and experience.

This is an exempt-level, benefited position. Learn more about UVA benefits .

This position is based in Charlottesville, VA, and must be performed fully on-site.

About UVA and the Community

To learn more about UVA and in the Charlottesville area, visit UVA Life and Embark CVA .

Additional Requirements

Background checks and pre-employment health screenings will be conducted on all new hires prior to employment.

How to Apply

Please apply online , by searching for requisition number R0085013. Complete an application with the following documents:

• Resume
• Cover Letter
• Contact information for three professional references

Upload all materials into the resume submission field. You can submit multiple documents into this one field or combine them into one PDF. Applications without all required documents will not receive full consideration.

Internal applicants: Search and apply for jobs on the UVA Internal Careers website .

Contact

For questions about the application process, please contact Jeremy Brofft, Senior Academic Recruiter at xmf9ad@virginia.edu . For questions about this position, please contact Dr. Jie Yang wfw7nc@virginia.edu .

The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA’s commitment to non-discrimination and equal opportunity employment .