Research Associate, Department of Neuroscience

Are you passionate about unraveling the mysteries of the human brain? Do you have a strong desire to contribute to groundbreaking discoveries in the field of neurodegenerative diseases? Look no further! The Lulu Jiang Lab at the University of Virginia (UVA) is seeking talented individuals to join our dynamic research team as Postdoctoral Research Associates.

Responsibilities include:

• Conducting experiments and data analysis related to ongoing research projects.
• Contributing to the development and implementation of research protocols.
• Collaborating with fellow researchers and scientists within and outside the lab.
• Presenting research findings at conferences and publishing in scientific journals.
• Assisting in the training and mentorship of junior lab members.

The Lulu Jiang Lab is dedicated to advancing our understanding of the intricate workings of the brain. At our lab, we have a strong emphasis on comprehending the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and other related dementia disorders. Our primary objective is to deepen our understanding of these disease conditions. To achieve this, we employ cutting-edge technologies in disease modeling, allowing us to recreate and study the pathological processes in a controlled environment. By utilizing these advanced techniques, we gain insights into the intricate molecular mechanisms that underlie the progression of these diseases. Moreover, our lab is dedicated to the development of innovative therapeutic strategies. We strive to translate our research findings into practical applications that could potentially lead to the discovery of novel treatments. By integrating our knowledge of disease mechanisms with targeted therapeutic approaches, we aim to make significant contributions to the field of neurodegenerative disease research. Overall, our lab is committed to advancing the understanding, diagnosis, and treatment of neurodegenerative diseases through the utilization of state-of-the-art technologies and the exploration of molecular mechanisms.

Our research focuses on several key areas that drive our scientific interests and contribute to the understanding and treatment of neurodegenerative diseases.

These areas include:

• Investigation of RNA modifications and epitranscriptomic mechanisms in the pathogenesis of Alzheimer's disease (AD) and related dementias. By studying how RNA modifications impact disease progression, we aim to uncover novel therapeutic targets and diagnostic markers.
• Exploration of neuron-glia interactions and neuroimmunological mechanisms underlying the progression of AD and Parkinson's disease (PD). Understanding the complex interplay between neurons and glial cells will provide crucial insights into the underlying mechanisms and potential avenues for therapeutic intervention.
• Utilization of iPSC-induced 3D human brain organoid models to study neurodegenerative diseases and enable precision medicine approaches. These advanced models allow us to recapitulate the complexity of the human brain, facilitating the identification of disease mechanisms and the development of personalized treatment strategies.
• Elucidation of the molecular mechanisms driving prion-like propagation in the Braak stages of AD. Investigating the spread of pathological proteins in the brain will contribute to our understanding of disease progression and may lead to the development of interventions that disrupt this process.
• Development of innovative genetic and small molecule therapeutics for neurodegenerative diseases. Our research aims to identify and optimize potential therapeutic targets, including genetic approaches and small molecules, with the goal of ultimately translating these findings into effective treatments for patients.

These research directions represent our current focus and ongoing projects, which collectively contribute to the advancement of knowledge and the development of new strategies for the management and treatment of neurodegenerative diseases.

With state-of-the-art facilities and a collaborative environment, we strive to foster creativity, innovation, and scientific excellence.

For more information about our department and our lab, please visit https://med.virginia.edu/neuroscience/ or contact Lulu Jiang at wpm5vs@virginia.edu .

The successful candidate will have the following qualifications and experience:

• Ph.D. degree in Neuroscience, Biology, Psychology, or a related.
• Strong background in neuroscience research techniques and methodologies.
• Experience with data analysis software (e.g., MATLAB, Python, R).
• Excellent organizational, communication, and problem-solving skills.
• Ability to work independently and as part of a team.

Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.

The position is a 12-month appointment with the possibility of renewal contingent upon satisfactory performance and the availability of funding.

This is a restricted position; continuation is dependent on funding and satisfactory performance. This position will remain open until filled. This is an exempt-level, benefitted position. The University will perform background checks on all new hires prior to employment. A pre-employment health screening is required. This position is located in Charlottesville, VA.

To Apply:

Please apply through Workday , and search for R0049795. Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs'. Complete an application online with the following documents:

• Cover letter highlighting your research experience and interests.
• Curriculum vitae (CV) with a list of publications (if applicable).
• Contact information for three professional references.

Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Applications that do not contain all required documents will not receive full consideration.

For questions about the application process, please contact Jessica Russo, Academic Recruiter, at sxv9zv@virginia.edu .

For more information on the benefits available to postdoctoral associates at UVA, visit postdoc.virginia.edu and hr.virginia.edu/benefits .

The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.